Locus Rank
20

Gene

Id
157
Gene Name
LRP1
Duplicated
False
Maternal
True
Gene Not Within Locus (Nearby
False
Gene Description
Mouse Phenotype
Mice homozygous for a null allele exhibit lethality during late organogenesis.
Additional Image
Allen Brain
Allen Regions
Zfin In Situ
Zfin Brain Areas
Published Zebrafish Pehnotype
Not In Allen Brain
False
ZFIN Link
http://zfin.org/ZDB-GENE-030131-7126
Allen Link
http://mouse.brain-map.org/gene/show/16741
More Additional Images
Papers
http://www.ncbi.nlm.nih.gov/pubmed/25500815

Locus Rank

Locus Rank
20
Genes in Region
LRP1 MYO1A NAB2 NDUFA4L2 NXPH4 R3HDM2 SHMT2 STAC3 STAT6 TAC3 TMEM194A
Associated Snps
rs12826178 (21)
rs324017 (103)
GWAS Region (hg19)
chr12:57428314-57682971
Genes Skipping
MYO1A - no allen brain, myosin; NDUFA4L2 - no allen brain, nadh dehydrogenase; NXPH4 - high in hindbrain of allen and jax knockout doesn't sound promising . . .; STAC3 - muscle (there is one 2015 paper hinting at calcium channels in brain, but zfin shows muscle expression only); TAC3 - is neuro, but a lot is known and seems like it's not this gene (has to do with puberty though . . ); TMEM194A - nothing is known, but not in allen brain
Ricopili Plot Surrounding Area
Distance On Each Side Of Locus In Above Plot
0.2 MB
Ricopili Plot
Gwas And Surrounding Region Pic
Gwas Region Pic
Genes In Locus Rank
NXPH4
R3HDM2
NAB2
LRP1
SHMT2
STAT6

Sequence 1

Ensembl Gene Name
lrp1ab
Harvard Allele
a293
Mutation Area - WT DNA Sequence
GTCAGACCTGCACAAACTCAGAGGGCTCCTACACCTGCAGCGGAGGGTGGGTTACCTGCCGCAACTGGACAACCGCTGCAAGGCCAAGAATGGTAGGACACATTTC
Mutation Area - Mutant DNA Sequence
GTCAGACCTGCACAAACTCAGAGGGCTCCTACACCTGCAGCTGTGTGGAGGGTTACCTGCCGCAACTGGACAACCGCTCATGCAAGGCCAAGAATGgtaggacacatttctttctgctggttcatcttgctctctgtctgctcttgctctaaaattgtcccctatgactggttttggggtctaaggtcacatatttgtaatctatgtacatctctatgtatgtgtatgtctatgtactgtatgttcaaagtctcttgacttcaaaaaatgtatcatattatgactgctgatttcattcatctgaaatgcagaggtgggttctcacgcccttactgatcatattcagaaatatcagtagatgtatttgtattgattctttattcagactatcaacagtagaatcagataaagtgtttgttaattgtagtcaaattaaatttaaaaatctgcttcaacttccatccctataatccaaaataatgattatttatccttatctatgtttaagACCCAGTGGATCGGCTCCCGTTCCTCCTTATAGCCAACTCCCAAAACATCCAAGCCACCTCTCTGAGTGGAGCAAACCCTATTACCATCAACGACAAACAGACCACCACAATGGACTTCATCTACGCCCAGGAGACCGTGTGCTGGATCCACATGGGCGACTCTCCCACTGCCTCGCAACTCAAGTGTGCCAAGTTTCCCAATGCCAAGAGCTTTACGGAGGAGAAGACCATTAACATCTCCCTCAGCCTGCACCgtaagacca
Guide RNA Target Sites
CTCCTACACCTGCAGCTGTGTGG
CATTCTTGGCCTTGCATGAGCGG
ATCCAAGCCACCTCTCTGAGTGG
CTTGGCACACTTGAGTTGCGAGG
Genotyping Primers
f, GTCAGACCTGCACAAACTCAGAG
r, gaaatgtgtcctacCATTCTTGGCC
Alignment of WT and Mutant Sequences w/ gRNA Targets (cyan) and Genotyping Primers (pink) Shown on WT Sequence
Allele
1bpD,3bpD
WT Genotyping Size
110
WT Protein Sequence
MPSCNANMLAVGLLYLGLVLALEVVDPTRAIEAPKTCSPKQFVCKDQVTCISKGWRCDGE
KDCPDGSDESPDICHHTQVTQCPPNEFECRGTDVCIHLSKLCDGVPDCTDGRDEGPHCRE
LASKCSIMDCQYNCSVTLSGPKCYCKNGYEVGEDGKTCKDFNECAVYGTCSQTCTNSEGS
YTCSCVEGYLPQLDNRSCKAKNDPVDRLPFLLIANSQNIQATSLSGANPITINDKQTTTM
DFIYAQETVCWIHMGDSPTASQLKCAKFPNAKSFTEEKTINISLSLHHMEQMAIDWLTGN
FYFVDNVDDRIFVCSKDGSICVILLDMELYSPKGIALDPAMGKVFFTDYGQTPKVERCDM
DGQNRTKLVDSKIVFPNGITLDLANKLVYWTDAYLDYIEVVDYEGKNRHTIIQGLLIEHL
YGLTVFENYLYATNSDNANMQPKTSVIRVNRFNSSDFQVVTRVDKGGALHVYHQRRQPTV
RSHACALDPFGKPGGCSDICLLANSHKTRTCRCRSGFSLGSDGKSCKKPEHELFLIYGKG
RPGVIRGMDMHSTVYDEHIVPIENLNNPRALDFHAETEFIYFADATSYIIGRQKLDGTER
DIIVKDGIHTVEGIAVDWMGQNLYWTDDGPKKTISVAKLEKASQTRKTLIEGKMTHPRAI
VVDPSHGMMYWSDWEEEPKEMNRGSIRKAWMDGSNAGILLTSKTVLWPNGLSLDIQQGLL
YWVDAYYDRIEMVLLNTTERRTVYEGQELNHPFGLCHHKNFLFWNEYRGGGIYKLDQNTK
KATLLRNERPPIYEIRTYDAQQQQIIGSNVCRANNGGCSSLCLLTPTGRSCACADDQILD
TDNKTCRANPSYVPPPQCQPGEFACKNNRCIQERWKCDGDNDCLDNSDETPDLCNQHTCP
ADRFKCQNNRCIPLRWLCDGDNDCGNDEDESNSTCLARTCPSNQYPCASGRCIPVSWMCD
LDDDCGDRSDEPASCAYPTCYPLTQFTCANGRCINVNWRCDNDNDCGDNSDEAGCSHSCS
SVQFKCNSGRCIPEYWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRMDGLCI
PMRWRCDGDTDCMDLSDEKNCEGVTHMCDPAVKFACKDSARCISKAWVCDRDSDCEDNSD
EENCEALECKLSHHVCASNDSICLPPEKLCDGKDDCPDASDEKLCNLCTVENGGCSHNCT
IAPGEGVLCSCPAGMELGTDNKTCQIQSFCAKHLKCSQRCVQEKATVKCACYEGWALGPD
GESCKSTDPFKPFIIFSNRHEIRRIDLYKGEFSVLVPGLRNTIALDFHFNQSSLYWTDVV
EDKIYRGKLSENGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTM
RTTLLAGEVEHPRAIALDPRDGILFWTDWDASSPRIEAASMSGEGRRTIHKETGIGGWPN
GLTVDYLERRILWIDARSDAIYSAAYDGSGLIEVLRGHEHLSHPFAVTLYGGEVYWTDWR
TNTLARANKWTGHNVTVVQRTNTQPFDLQVFHPSRQPQAPNPCAANDGKGPCSHLCLINY
NQTFSCACPHLMKLKADKHTCYEYRQFLLYARQIEIRGVDIDNPYYNYIISFTVPDIDNV
TVVDYDALEHRIYWSDVRTQTIKRAFINGTGVETVVSADLPNAQGLAVDWISRNLFWTSY
DTNKKQINVARLDGSFKNAVIHGQGLDKPHCLVLHPILGKLYWLDGDNISMANMDGTNHT
LLFTNQKGPVGLSIDFDSEQLYWISSRNSTINHCKMDGSGLEVIESVKGKLTKATALAIM
GDKLWWADQSTDQIGTCDKSDGGNWKVLRYHTSPMMHMKIYNESVHQIGTNLCSKNNGDC
SQLCLPTSPSTRACMCTAGYSLKSGQQSCEGMGSFLLYSVHEGIRGIPLDPSDKSDALVP
VSGTSLAVGIDFHADNDTIYWVDMGLSTISRAKRDQTWREDIVTNGIGRVEGITVDWIAG
NIYWTDQGFDVIEVARLNGSFRYVVISHGLDKPRAIAVHPEKGYLFWTEWGQYPRIERSR
LDGSERVVLVNVSISWPNGISIDYQEGLLYWCDARTDKIERINLETGENRELVLSSNNMD
MFAVSVFEDYIYWSDRTHANGSIKRGNKDNATDMVYLRTGIGVQLKDIKVFNRARQQGTN
VCKVNNGGCEQLCLFRGNGNRTCACAHGMLAEDGHSCRDYDGYLLYSERTILKSIHLSDE
TNLNAPIKPFEDPEHMKNVIALTFDYRGGGGKGANRIFYSDIHFGNIQHINDDGSDRKTI
VDNVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQSRSGAFDRDTVVTMSGDDHPRAFV
LDECQDLMFWTNWNEQSPSIMRASLSGANVLVIIGNNIRTPNGLAIDHRAEKLYFSDATF
DKIERCEYDGSRRFVVLKNEPVHPFGLAVYGDYIFWTDWVRRAVLRADKYGRDMKVLRAD
IPQQPMGIIAVAKDTNSCEFSPCLTNNGGCQDLCLITSEGRVNCSCRGERKLLGDNTCVA
ENTTCNSVDEFECGNGDCIDYSLTCDSLAHCKDKSDEKQAYCANRMCKKGYRRCINGRCI
KHSSWCDSTDDCGDGSDELPCNMTLCSAAEFQCKDGSCITNSSRCNQVVDCEDASDEMNC
SPTDCSSYYLLGVKGMTFERCEFTTLCFAPSWRCDGSNDCGDFSDERNCPEKRQQKCSEN
NFACPSGRCIPMSWTCDKENDCEDGADEAHCEKFFQFCASNQFECGNHRCIFKTWVCDGT
DDCGDGTDEDSRCKAKTCGPDSFQCPGSHVCILQRWVCDGDKDCPDGGDEGLKAGCVFNK
TCDDTEFQCQNSQCIPKNFMCDHDIDCRDGSDESPECEYPTCGPNDFHCANGQCLKQKNW
ACDGEFDCRDQSDEAPKNLQCTDTESRCNDTAFLCSSGKCVNETLLCDNNNDCGDGSDEN
NCFVNECLNSKLSGCSQLCEDLKIGFKCRCNAGFRLKQDGKTCVDLDECSTVYPCSQRCI
NTHGSFHCLCVDGFVPRPDDHTSCKSTAEEEPFLIFANRYYLRKLNLDGSNYTLIKQGLN
NAVALDYHYAEQMIYWTDVTTQGSMIRRMHINGSNVQVLHRTSLSNPDGLAVDWVGGNLY
WCDKGRDTIEVSKLNGAYRSVLVNSGLREPRAVAVDVRNGYLYWSDWGDVPHIGRIGMDG
TDRQIIIQDKITWPNGLTLDFINDRIYWADAREDYIAFASLDGSNRHTVLNHDIPHIFAM
TLFEEFIYWTDWETKSINRAHKTLGTNKTLLISTLHRPMDIHIFHPSRQPEVSGHPCQED
NGGCSNLCLLSPGGGYKCACPTNFYLAADGKQCLSNCTASQFVCKNDKCIPFWWKCDTED
DCGDRSDEPADCPEFKCRPGQFQCGTGLCTNPAYICDGDNDCQDNSDEANCDIHVCLPSQ
FKCSHPSRCIPGILRCNGQNNCGQGEDEKDCPEVTCAPNQFQCAITKRCIPRVWVCDRDY
DCVDESDEPANCTQMKCGVDEFRCKDSGRCIPSRWTCDGEDDCGDASDEPKEECDERTCE
PYQFRCKNNRCVPGRWQCDYDNDCGDNSDEEKCVPRQCSESEFACSNGRCIAGRWKCDGD
HDCSDGSDEDGCDLKCEEDQFQCKNGHCIPLPWRCDADVDCLDGSDEERCEITEVRHCSS
EEFQCNNTLCKPLSWKCDGEDDCGDNSDENPEACRHFQCPPTRNFRCRNNRVCLTRSKLC
DGVDNCGDNSDEASCDYESTCDKDQFRCTNGKCISANLRCNFFNDCEDYGSDEIGCKTDT
MLNDCKSNKSLCGDGDEAHCVSNGTDTFCSCKPGFQSVRHNTCEDKDECKQFGVCSHVCN
NTKGSYKCSCHKYFTRINHTCKADGQNSNKQVLYIADDNEIRSLNPGMPNWVYEQTFQGD
NNVRIDAMDLHVKTNRIFWTNWHTYGISCFQLPSQSSASGPTSNSHRHTRQSEGTVSNLE
IPGLKMPRGIAVDWVAGNLYWTDSGRDVIEVAQITGQHRKTLISGMIDEPHAIVVDPQRG
TMYWTDWGNHPKIETAAMDGTLRQTLVHENIQWPTGLAVDYFNERLYWADSKLSVISSVR
LDGSDPVVAVSNLKNNLLRPYSIDIFEDYIYGVTHTNNIVFRVNKFGKGQAENLTTGINH
ATDIVLYHRYKQPEMTNPCDRKKCEWLCLLSPSGPVCICPNDHVPDNGTCVKVQPPDQFP
FSPTCDLQCQNGGSCYLNPLKNPKCRCPTSYRGERCEINQCRDYCQNRGTCSPSRTGAPT
CRCQTGFTGPRCNLYICENYCQNGGNCAVSLGNQPTCRCPPGFLGDQCQYRQCEDFCKND
GQCLELNNGTKHCQCSDKFFGPQCELDKCEYCGTGKCEKLQTGITCKCADNTKRPTCYTC
DDFCIEGQCSVDTYTNLPQCRCHTGWSGFRCELNVAPVQNSDSGNTPSVVIPVMLLLLLA
LLVVAAILWYKKRMRGAKGFQHQRMTNGAMNVEIGNPAYKIYEGEPDDDAGELLDSDFTL
DPDKPTNFTNPVYATLYMGAHNSRNSLASTDEKKELLSAGDDDMGDPLA-
Mutant Protein Sequence
MPSCNANMLAVGLLYLGLVLALEVVDPTRAIEAPKTCSPKQFVCKDQVTCISKGWRCDGE
KDCPDGSDESPDICHHTQVTQCPPNEFECRGTDVCIHLSKLCDGVPDCTDGRDEGPHCRE
LASKCSIMDCQYNCSVTLSGPKCYCKNGYEVGEDGKTCKDFNECAVYGTCSQTCTNSEGS
YTCSGGWVTCRNWTTAARPRMTQWIGSRSSL-
Mutant Genotyping Size
106

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