Locus Rank
3

Gene

Id
10
Gene Name
ARL3
Duplicated
False
Maternal
True
Gene Not Within Locus (Nearby
None
Gene Description
ADP-ribosylation factor-like 3 is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL3 binds guanine nucleotides but lacks ADP-ribosylation factor activity. Has to do with release of cargo from dynein/dynactin.
Mouse Phenotype
Mice homozygous for a gene trapped allele are born at sub-Mendelian ratios, are small and sickly, fail to thrive, and die by 3 weeks of age exhibiting photoreceptor degeneration and abnormal epithelial cell proliferation and cyst formation in the kidney, liver, and pancreatic tubule structures.
Additional Image
Allen Brain
Allen Regions
Zfin In Situ
Zfin Brain Areas
Published Zebrafish Pehnotype
Not In Allen Brain
False
ZFIN Link
None
Allen Link
None
More Additional Images
Papers

Locus Rank

Locus Rank
3
Genes in Region
ARL3, AS3MT, C10orf32, CNNM2, CYP17A1, INA, NT5C2, PCGF6, PDCD11, SFXN2, TAF5, TRIM8, USMG5, WBP1L
Associated Snps
rs11191419 (shown), chr10_104957618_I, rs7907645, rs55833108
GWAS Region (hg19)
chr10:104423800-105165583
Genes Skipping
AS3MT, NT5C2, PCGF6, PDCD11, SFXN2, TAF5, TRIM8, USMG5, WBP1L
Ricopili Plot Surrounding Area
Distance On Each Side Of Locus In Above Plot
0.2 MB
Ricopili Plot
Gwas And Surrounding Region Pic
Gwas Region Pic
Genes In Locus Rank
NT5C2
CYP17A1
C10ORF32
CNNM2
INA
ARL3

Sequence 1

Ensembl Gene Name
arl3
Harvard Allele
a233
Mutation Area - WT DNA Sequence
tatgacgtcatgttgcacgcattgcaaaaactcagatcactgtacattctgcgccttttagGGTTTGTTGTCCATTTTACGGAAACTGAAGAGCACCCCAGATCAGGAGGTGAGGATATTGCTTCTAGGACTGGACAATGGGGGAAAGACGACCTTACTGAAACAGCTAGCATCTGAAGACATCACTCATATCACTCCAACACAGgtacagacacggttactgtaactactgcattcacatctccagataaagctaatta
Mutation Area - Mutant DNA Sequence
tatgacgtcatgttgcacgcattgcaaaaactcagatcactgtacattctgcgccttttagGGTTTGTTGTCCATTTTACGGAAACTGAAGAGCACCCCAGGAGGTGAGGATATTGCTTCTAGGACTGGACAATGGGGGAAAGACGACCTTACTGAAACAGCTAGCATCTGAAGACATCACTCATATCACTCCAACACAGgtacagacacggttactgtaactactgcattcacatctccagataaagctaatta
Guide RNA Target Sites
tgtacattctgcgccttttagGG
GAAGAGCACCCCAGATCAGGAGG
GCTTCTAGGACTGGACAATGGGG
CACTCATATCACTCCAACACAGg
Genotyping Primers
f, ctgcgccttttagGGTTTGTTGTCC
r, CTGTTTCAGTAAGGTCGTCTTTCCCC
Alignment of WT and Mutant Sequences w/ gRNA Targets (cyan) and Genotyping Primers (pink) Shown on WT Sequence
Allele
5bpD
WT Genotyping Size
118
WT Protein Sequence
MGLLSILRKLKSTPDQEVRILLLGLDNGGKTTLLKQLASEDITHITPTQGFNIKSVQSQG
FKLNVWDIGGQRKIRPYWRNYFENTDVLIYVIDSADRKRFEETGQELAELLDEEKLSGVP
VLVFANKQDLLTAAPASEIAEGLNLHTIRDRVWQIQSCSALTGEGVQDGMNWVCKSVNAK
RK-
Mutant Protein Sequence
MGLLSILRKLKSTPGGEDIASRTGQWGKDDLTETASI-
Mutant Genotyping Size
113
Ribosome Profiling Development
Transcript Plot

Behavior Data

Behavior Data Summary
None
Behavior Data Description 1
Dark flash block 1 start Merged section Pvalue = not significant 30 het vs 18 hom ribgraph_mean_ribbon_fullboutdata_dpix_a0darkflash103.png
Behavior Data Graph 1
Behavior Data Description 2
Day all prepulse tap Merged section Pvalue = 0.0167 30 het vs 18 hom ribgraph_mean_ribbon_fullboutdata_dpix_dayprepulseinhibition100d.png
Behavior Data Graph 2
Behavior Data Description 3
Features of movement entire protocol Graph Pvalue = 0.00684 Merged section Pvalue = 0.0196 30 het vs 18 hom ribgraph_mean_ribbonbout_aveboutdisp_10min_combo.png
Behavior Data Graph 3
Behavior Data Description 4
Frequency of movement entire protocol Graph Pvalue = 0.000561 Merged section Pvalue = 0.00403 30 het vs 18 hom ribgraph_mean_ribbonbout_dpixnumberofbouts_10min_combo.png
Behavior Data Graph 4
Behavior Data Description 5
Location in well entire protocol Graph Pvalue = not significant Merged section Pvalue = not significant 30 het vs 18 hom ribgraph_mean_ribbonbout_averhofrac_10min_combo.png
Behavior Data Graph 5
Behavior Data Description 6
None
Behavior Data Graph 6
None
Behavior Data Description 7
None
Behavior Data Graph 7
None
Behavior Data Description 8
None
Behavior Data Graph 8
None
Behavior Data Description 9
None
Behavior Data Graph 9
None
Behavior Data Description 10
None
Behavior Data Graph 10
None
Behavior Data Description 11
None
Behavior Data Graph 11
None
Behavior Data Description 12
None
Behavior Data Graph 12
None
Behavior Data Description 13
None
Behavior Data Graph 13
None
Behavior Data Description 14
None
Behavior Data Graph 14
None