Locus Rank
3

Gene

Id
6
Gene Name
CNNM2
Duplicated
True
Maternal
True
Gene Not Within Locus (Nearby
False
Gene Description
This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein family contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play an important role in magnesium homeostasis by mediating the epithelial transport and renal reabsorption of Mg2+. Mutations in this gene are associated with renal hypomagnesemia.
Mouse Phenotype
Additional Image
Allen Brain
Allen Regions
Zfin In Situ
Zfin Brain Areas
cnnm2a (see in situ): Midbrain-hindbrain boundary
Published Zebrafish Pehnotype
Not In Allen Brain
False
ZFIN Link
http://zfin.org/search?q=cnnm2&fq=category%3A%22Gene+%2F+Transcript%22&category=Gene+%2F+Transcript&fq=type%3A%22Gene%22
Allen Link
http://mouse.brain-map.org/gene/show/60853
More Additional Images
Papers

Locus Rank

Locus Rank
3
Genes in Region
ARL3, AS3MT, C10orf32, CNNM2, CYP17A1, INA, NT5C2, PCGF6, PDCD11, SFXN2, TAF5, TRIM8, USMG5, WBP1L
Associated Snps
rs11191419 (shown), chr10_104957618_I, rs7907645, rs55833108
GWAS Region (hg19)
chr10:104423800-105165583
Genes Skipping
AS3MT, NT5C2, PCGF6, PDCD11, SFXN2, TAF5, TRIM8, USMG5, WBP1L
Ricopili Plot Surrounding Area
Distance On Each Side Of Locus In Above Plot
0.2 MB
Ricopili Plot
Gwas And Surrounding Region Pic
Gwas Region Pic
Genes In Locus Rank
NT5C2
CYP17A1
C10ORF32
CNNM2
INA
ARL3

Sequence 1

Ensembl Gene Name
cnnm2a
Harvard Allele
a357
Mutation Area - WT DNA Sequence
CTAAACCGGGCTGGATCATTGACTGTTATATTCCTAATTGTCAGCAGTTGTCTGATCAAAAGCATTGATGGTAAAGACCCGTCAGAAGAGACTGTCATCATTGGCCTCCGCCTCGAAGACACCGACGAGGTGTCTTTTATGGACAGAGGCTTTTTGCGCGTCAGCGAGCGATCTCGTGTCAGATTAAGGGTCTATGGGCAAAACATCAACAACGAGACGTGGTCCAAACTCGCCTTCACGGAACACCGCAGCAACGCACCTGCGGAGAGCCTGAGCCCCGGAGACGCACCTGCCTCGCATCCCTGCGGCATCCGATCCTCCGATATCATCATCCTTCCCACCATGGAGGTAAACAGAAAGACTTCTGGGATTATCGAGCTCGAGGTGAAGCCTCTGCG
Mutation Area - Mutant DNA Sequence
CTAAACCGGGCTGGATCATTGACTGTTATATTCTTAATTGTCAGCAGTTGTCTGATCAAAAGAAGAGACTGTCATCATTGGCCTCGAAGACACCGACGAGGTGTCTTTTATGGACAGAGGCTTTTTGCGCGTCAGCGAGCGATCTCGTGTCAGATTAAGGGTCTATGGGCAAAACATCAACAACGAGACGTGGTCCAAACTCGCCTTCACGGAACACCGCAGCAACGCACCTGCGGAGAGCCTGAGCCCCGGAGACGCACCTGCCTCGCATCCCTGCGGCATCCGATCCTCCGATATCATCATCCTTCCCACCATGGAGGTAAACAGAAAGACTTCTGGGATTATCGAGCTCGAGGTGAAGCCTCTGCG
Guide RNA Target Sites
TGATGACAGTCTCTTCTGACGGG
CGTCGGTGTCTTCGAGGCGGAGG
GCGAGGCAGGTGCGTCTCCGGGG
TGTTTACCTCCATGGTGGGAAGG
Genotyping Primers
f, GCTAAACCGGGCTGGATCATTGACTGT
r, CGCAGAGGCTTCACCTCGAGCT
Alignment of WT and Mutant Sequences w/ gRNA Targets (cyan) and Genotyping Primers (pink) Shown on WT Sequence
Allele
23bpD,6bpD
WT Genotyping Size
398
WT Protein Sequence
MAEQWTAVPTSNMAALNRAGSLTVIFLIVSSCLIKSIDGKDPSEETVIIGLRLEDTDEVS
FMDRGFLRVSERSRVRLRVYGQNINNETWSKLAFTEHRSNAPAESLSPGDAPASHPCGIR
SSDIIILPTMEVNRKTSGIIELEVKPLRKTEKSKTYYLCTAIGTPGAQDSWSEHTWVYHE
GHDTKVIVVEEKKFLLPFWLQVIFIAMLLCLSGMFSGLNLGLMALDPMELRIVQNCGTEK
EKHYAKAIEPVRSQGNYLLCSLLLGNVLVNTTLTILLDDIAGSGLIAVVVSTIGIVIFGE
IVPQAICSRHGLAVGANTIFLTKFFMILTFPASYPVSKLLDHVLGQEIGTVYNREKLLEM
LRVTDPYNDLVKEELNIIQGALELRTKTVEDVMTPLRDCFMISGDAILDFATMSEIMESG
YTRIPVYEGERCHIVDLLFVKDLAFVDPDDCTPLKTITKFYSHPLHFVFNDTKLDAMLEE
FKKGKSHLAIVQRVNNEGEGDPFYEVLGIVTLEDVIEEIIKSEILDETDLYTDNKTKKKI
AHREKKQDFSAFKPTENELRVKISPQLLLATLRFLATEVESFSATQMSEKILLRLLKHPN
VIQELKYDDKDKKMSEHYLFHRNKPVDYFILILQGKVEVEAGKEGMKFEAGAFSYYGVLS
LTSSPVPLSLSRTFVVSRAESLAGSPENKSPPRPFGLNHSDSLNRSDRMEAVTPTLGSSN
NQLNSFLQVYVPDYSVRAVSDLLYIKVTRQQYQNALMASRMDKTPQSTDSEFTKIELTFT
EHQDGPLEESATLLTTNSHKPNHTAHNDGVV-
Mutant Protein Sequence
MAEQWTAVPTSNMAALNRAGSLTVIFLIVSSCLIKRRDCHHWPRRHRRGVFYGQRLFARQRA
ISCQIKGLWAKHQQRDVVQTRLHGTPQQRTCGEPEPRRRTCLASLRHPILRYHHPSHHGGK
QKDFWDYRARGEASAQNGKK-
In Situ Probe Sequence
ATTGCCATGTTGTTGTGCTTGTCTGGGATGTTCAGCGGGCTGAATCTGGGTCTGATGGCGCTGGATCCCATGGAGCTCCGGATTGTGCAAAACTGCGGGACCGAGAAGGAGAAGCATTACGCGAAGGCGATCGAGCCTGTCCGAAGCCAAGGAAACTACCTGCTGTGCTCGTTGCTGCTGGGAAATGTCCTGGTCAACACTACTTTGACTATACTTCTCGATGACATCGCAGGGTCAGGGCTGATCGCTGTGGTGGTGTCCACTATAGGGATAGTGATATTTGGGGAGATCGTGCCTCAGGCCATCTGCTCCAGGCACGGACTCGCTGTAGGCGCGAATACAATATTCTTGACTAAATTTTTTATGATCCTCACTTTCCCAGCATCCTATCCGGTCAGCAAACTCCTGGACCACGTGCTGGGGCAGGAGATTGGAACTGTGTACAACAGGGAGAAGCTGCTGGAGATGCTGAGGGTGACCGATCCATATAATGACCTGGTCAAAGAGGAGCTCAACATCATCCAGGGCGCTCTGGAGCTCAGGACTAAAACCGTGGAGGATGTCATGACACCTCTGCGGGACTGCTTCATGATTTCTGGTGATGCCATACTGGACTTCGCCACCATGTCTGAGATCATGGAGAGTGGCTACACTCGGATACCTGTGTATGAGGGTGAGAGATGTCACATTGTGGACCTGCTGTTTGTCAAGGACTTGGCCTTTGTGGATCCAGATGACTGCACGCCTCTGAAAACCATCACCAAGTTCTACAGCCACCCTCTGCACTTTGTCTTCAACGATACAAAGCTGGATGCCATGCTGGAGGAGTTTAAAAAAGGTAAATCCCATCTGGCCATTGTCCAAAGAGTGAATAATGAAGGAGAGGGAGACCCGTTCTATGAAG
Mutant Genotyping Size
369
Ribosome Profiling Development
Transcript Plot

Sequence 2

Ensembl Gene Name
cnnm2b
Harvard Allele
a258
Mutation Area - WT DNA Sequence
CAGAACCGTCGGTTCCAGTACCCCCTCGAAAAATGGCGTCACTCAGCCGGGTCCGAGCCTTTACTCTGATTTTCTTAACTGCAAGCAGTTGTTTAATTACTCCCACAAGTGGCAAGGAAGGAGGGGGAGAGGAGACGGTCATCATCGGGCTGCGGCTGGAGGACACGGACGACATTTCCTTCATGGACAGGGGCTTTTTGCGGGTCAGCGAGAGGTCTCGGGTGAGATTGAGGGTGTACGGGCAAAACATCAACAACGAGACTTGGTCCAAAATCGCATTTACGGAGCACGAGAGGAGCCGAGTGATCGGCAACATCGACAGCTCTTCGGGGGACAACCAGAGTCAGGAGGACACGTCGGGCTTGCACCCCTGCGGCATCAGAACTTCGGATATTCTGATCTTGCCCAACATCGTTTTAAACCGCAAGACGTCTGGCACCGTGGAGATAGAGGTCAAACCTCTGCGAAAGACTGAGCGGAGCAAAGCGTACTACCTGTGCATCGCCACCTCCACACCTGCTGTGGCCGGAGCGCACGACCCGTGGACCGAGAACACGTGGATCTATCACGATGGAGAGGACACCAAAGTGATCGTGGTGGAGGAGAAAAAGTTCCTGCTGCCCTTCTGGCTCCAGGTCATCTTCATTTCTATGCTGCTCTGCCTCTCGGGCATGTTCAGCGGCTTGAACTTGGGGCTGATGGCGCTGGACCCCATGGAG
Mutation Area - Mutant DNA Sequence
CAGAACCGTCGGTTCCAGTACCCCCTCGAAAAATGGCGTCACTCAGCCGGGTCCGAGCCTTTACTCTGATTTTCTTAACTGCAAGCAGTTGTTTAATTACTCCCACAAGTGGCAAGGAAGCATCTTCAGGACCTGGAGCATCTTCATTTCTATGCTGCTCTGCCTCTCGGGCATGTTCAGCGGCTTGAACTTGGGGCTGATGGCGCTGGACCCCATGGAG
Guide RNA Target Sites
TGGCAAGGAAGGAGGGGGAGAGG
GCAACATCGACAGCTCTTCGGGG
CCGCAAGACGTCTGGCACCGTGG
GAAGATGACCTGGAGCCAGAAGG
Genotyping Primers
f, CAGAACCGTCGGTTCCAGTACCCC
r, CTCCATGGGGTCCAGCGCC
wt_f, TAGAGGTCAAACCTCTGCGAAAGACTG
PCR can be run with mix of all three primers.
Alignment of WT and Mutant Sequences w/ gRNA Targets (cyan) and Genotyping Primers (pink) Shown on WT Sequence
Allele
499bpD
WT Genotyping Size
272
WT Protein Sequence
MAEPSVPVPPRKMASLSRVRAFTLIFLTASSCLITPTSGKEGGGEETVIIGLRLEDTDDI
SFMDRGFLRVSERSRVRLRVYGQNINNETWSKIAFTEHERSRVIGNIDSSSGDNQSQEDT
SGLHPCGIRTSDILILPNIVLNRKTSGTVEIEVKPLRKTERSKAYYLCIATSTPAVAGAH
DPWTENTWIYHDGEDTKVIVVEEKKFLLPFWLQVIFISMLLCLSGMFSGLNLGLMALDPM
ELQIVQNCGTEKEKNYARKIEPVRSQGNYLLCSLLLGNVLVNTTLTILLDDIAGSGLIAV
VMSTIGIVIFGEIVPQAICSRHGLAVGANTIFLTKFFMLLTFPASYPVSKLLDYLLGQEI
GTVYNREKLLEMLRVTDPYNDLVKEELNIIQGALELRTKTVEDVMTPLRDCFMITGDATL
DFNSMSEIMESGYTRIPVFEGDRSNIVDLLFVKDLAFVDPDDCTPLKTITKFYSHPLHFV
FNDTKLDAMLEEFKKGKSHLAIVQRVNNEGEGDPFYEVLGIVTLEDVIEEIIKSEILDET
DLYTDNKTKKKITHRERKQDFSAFKHMDNEMKVKISPQLLLATLRFLATEVEPFSPSQMS
EKILLRLLKHPNVIQEVKYNDKNKKAIEHYLFHRNKPVDYFILVLQGKVEVEAGKEGLRF
EAGAFSSYGMMALTASPENKSPPRSFGLNHSDSLNRSERIEVITPSLGSSNNQLNAFLQI
YVPDYSVRAVSDVQYIKVTRQQYQNAVMASRIDKTPQSSESEYTKIEMALTELHDGLTDE
TTTLFNQTQNCVVHNKSNHTGHSEGPI-
Mutant Protein Sequence
MAEPSVPVPPRKMASLSRVRAFTLIFLTASSCLITPTSGKEASSGPGASSFLCCSASRACSAA-
In Situ Probe Sequence
ATGGCAGAACCGTCGGTTCCAGTACCCCCTCGAAAAATGGCGTCACTCAGCCGGGTCCGAGCCTTTACTCTGATTTTCTTAACTGCAAGCAGTTGTTTAATTACTCCCACAAGTGGCAAGGAAGGAGGGGGAGAGGAGACGGTCATCATCGGGCTGCGGCTGGAGGACACGGACGACATTTCCTTCATGGACAGGGGCTTTTTGCGGGTCAGCGAGAGGTCTCGGGTGAGATTGAGGGTGTACGGGCAAAACATCAACAACGAGACTTGGTCCAAAATCGCATTTACGGAGCACGAGAGGAGCCGAGTGATCGGCAACATCGACAGCTCTTCGGGGGACAACCAGAGTCAGGAGGACACGTCGGGCTTGCACCCCTGCGGCATCAGAACTTCGGATATTCTGATCTTGCCCAACATCGTTTTAAACCGCAAGACGTCTGGCACCGTGGAGATAGAGGTCAAACCTCTGCGAAAGACTGAGCGGAGCAAAGCGTACTACCTGTGCATCGCCACCTCCACACCTGCTGTGGCCGGAGCGCACGACCCGTGGACCGAGAACACGTGGATCTATCACGATGGAGAGGACACCAAAGTGATCGTGGTGGAGGAGAAAAAGTTCCTGCTGCCCTTCTGGCTCCAGGTCATCTTCATTTCTATGCTGCTCTGCCTCTCGGGCATGTTCAGCGGCTTGAACTTGGGGCTGATGGCGCTGGACCCC
Mutant Genotyping Size
220
Ribosome Profiling Development

Behavior Data

Behavior Data Summary
None
Behavior Data Description 1
Dark flash block 1 start Merged section Pvalue = 0.0184 16 hethom vs 12 homhom ribgraph_mean_ribbon_fullboutdata_dpix_a0darkflash103.png
Behavior Data Graph 1
Behavior Data Description 2
Day all prepulse tap Merged section Pvalue = 0.0129 16 hethom vs 12 homhom ribgraph_mean_ribbon_fullboutdata_dpix_dayprepulseinhibition100d.png
Behavior Data Graph 2
Behavior Data Description 3
Features of movement entire protocol Graph Pvalue = 0.0208 Merged section Pvalue = 0.0226 might not repeat 18 hethet vs 23 homhet ribgraph_mean_ribbonbout_aveboutdisp_10min_combo.png
Behavior Data Graph 3
Behavior Data Description 4
Frequency of movement entire protocol Graph Pvalue = 0.0107 Merged section Pvalue = 0.0134 16 hethom vs 12 homhom ribgraph_mean_ribbonbout_dpixnumberofbouts_10min_combo.png
Behavior Data Graph 4
Behavior Data Description 5
Location in well entire protocol Graph Pvalue = 0.00252 Merged section Pvalue = 0.00649 18 hethet vs 23 homhom ribgraph_mean_ribbonbout_averhofrac_10min_combo.png
Behavior Data Graph 5
Behavior Data Description 6
Dark flash Graph Pvalue = 0.00231 18 hethet vs 23 homhom boxgraph_pd__ribgraph_mean_ribbon_fullboutdatamax_dist_ddarkflash103.png
Behavior Data Graph 6
Behavior Data Description 7
Features of movement Graph Pvalue = 0.00301 17 homhet vs 12 homhom ribgraph_mean_ribbonbout_aveboutdist_min_combo.png
Behavior Data Graph 7
Behavior Data Description 8
Frequency of movement Graph Pvalue = 0.001 14 hethet vs 16 hethom ribgraph_mean_ribbonbout_dpixnumberofbouts_min_day2night1.png
Behavior Data Graph 8
Behavior Data Description 9
Location in well Graph Pvalue = 0.00123 18 hethet vs 23 homhom ribgraph_mean_ribbonbout_averhofrac_min_combo.png
Behavior Data Graph 9
Behavior Data Description 10
PPI tap Graph Pvalue = 0.000592 16 hethom vs 12 homhom boxgraph_pd__ribgraph_mean_ribbon_latencyresponse_dpix_dayprepulseinhibition100b.png
Behavior Data Graph 10
Behavior Data Description 11
Strong tap Graph Pvalue = 0.00417 14 hethet vs 17 homhet boxgraph_pd__bigmovesribgraph_mean_ribbon_peakspeed_nightprepulseinhibition102.png
Behavior Data Graph 11
Behavior Data Description 12
Tap habituation Graph Pvalue = 0.0102 16 hethom vs 12 homhom boxgraph_pd__ribgraph_mean_ribbon_freqresponse_dpix_nighttaphab102.png
Behavior Data Graph 12
Behavior Data Description 13
Weak tap Graph Pvalue = 0.00366 17 hethet vs 17 homhom boxgraph_pd__ribgraph_mean_ribbon_peakdpix_nightprepulseinhibition100a.png
Behavior Data Graph 13
Behavior Data Description 14
None
Behavior Data Graph 14
None