schizophrenia gene search

Made

CYP17A1
C10ORF32
CNNM2
INA
ARL3

Locus Rank

Gene

122

Gene Name

INA

Duplicated

True

Maternal

False

Gene Not Within Locus (Nearby

False

Gene Description

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene is a member of the intermediate filament family and is involved in the morphogenesis of neurons.

Mouse Phenotype

Additional Image

Allen Brain

Allen Regions

Zfin In Situ

Zfin Brain Areas

Published Zebrafish Pehnotype

Not In Allen Brain

False

ZFIN Link

None

Allen Link

None

More Additional Images

Papers

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0088631

Locus Rank

Genes in Region

ARL3, AS3MT, C10orf32, CNNM2, CYP17A1, INA, NT5C2, PCGF6, PDCD11, SFXN2, TAF5, TRIM8, USMG5, WBP1L

Associated Snps

rs11191419 (shown), chr10_104957618_I, rs7907645, rs55833108

GWAS Region (hg19)

chr10:104423800-105165583

Genes Skipping

AS3MT, NT5C2, PCGF6, PDCD11, SFXN2, TAF5, TRIM8, USMG5, WBP1L

Ricopili Plot Surrounding Area

Distance On Each Side Of Locus In Above Plot

0.2 MB

Ricopili Plot

Gwas And Surrounding Region Pic

Gwas Region Pic

Genes In Locus Rank

NT5C2
CYP17A1
C10ORF32
CNNM2
INA
ARL3

Sequence 1

Ensembl Gene Name

inaa

Harvard Allele

a285

Mutation Area - WT DNA Sequence

gatcttgtcttaacagtcactaccagagggaatatgacaggctgctaaatgggacagtccgccgggtatataatggcaagcacaccagttttagactcccttagttgtgacGAAGATGAGTTACGGATCAGACCACTACATGTCTTCATCCTACAGAAAATTGTTCGGGGACAACCCTCGTTTTGCCGGCTCTAGAATGAGCAATGTCTCTCCCCGGAGCTCCATGTCCTCCAGCGGCTTCAGGTCTCAGTCTGTCTCCCGCAGCAGCGCCTCTCCTGCGGGCTACTATAAAAGATCGGGCCGGTCATCTTCATTCTCGCCGGTCCATTTCGACAGCGTGGATTTCTCTCAAACCTCTGTTTTGAACAACGAGTTTAAAATCGTTCGAACCAATGAAAAGGAACAGCTGCAAGGACTCAATGACCGGTTCGCGATGTTTATCGAGAAAGTGCGCAATCTGGAGCAGCACAATAAAGTGCTGGAGACCGAACTGGTGAGTCTGCGCCAGAGGCAGAACGAGCCGTCCAGACTTGCTGAACTCTATCAGCAGGAGATCCGGGACCTGCGAGCTCAGGTAGACGAGCTGAACAACGAGAAATCGCACATTCTCATTGAACGCGACAGCATCGAGGAAGACTTGCAGAAACTTCGAGGCAAGTTTGAGGAAGAGATCCGAGCGCGCGAGGAGGCAGAGCAGACGCTCAGATCCTACAAGAAAGATGTGGATGATGCCACCATGGTCCGCGTGGACCTGGAGAGAAAGGTCGAATCACTTTTAGATGAGATAAATTTTCTGAGGAAGGTGCATGACGAAGAGGTGACCGAGTTGACTAATATGATCCAGGCGGCACAGATATCTGTGGAAGTGGAGTTGTCCAAGCCTGATCTGACCTCGGCCCTCAAGGACATTCGCGGCCAGTATGAG

Mutation Area - Mutant DNA Sequence

GATCTTGTTCTTAACAGTCACTACCAGAGGGAATATGACAGGCTGCTAAATGGGACAGTCCGCCGGGTATATAATGGCAAGCACACCAGTTTTAGACTCCCTTAGTTGTGACGAAGATGAGTTACGGATCAGACCACTAAGTCATCGAGGAAGACTTGCAGAAACTTCGAGGCAAGTTTGAGGAGGAGATCCGAGCGCGCGAGGAGGCAGAGCAGACGCTCAGATCCTACAAGAAAGATGTGGATGATGCCACCATGGTCCGCGTAGACCTGGAGAGAAAGGTCGAATCACTTTTAGATGAGATCAATTTTCTGAGGAAGGTGCATGACGAAGAGGTGACCGAGTTGACTAATATGATCCAGGCGGCACAGATATCTGTGGAAGTGGAGTTGTCCAAGCCTGATCTGACCTCGGCCCTCAAGGACATTCGCGGCCAGTATGAG

Guide RNA Target Sites

TGTAGGATGAAGACATGTAGTGG
GCCGGTCCATTTCGACAGCGTGG
CATTGAACGCGACAGCATCGAGG
TGATGCCACCATGGTCCGCGTGG

Genotyping Primers

f, gatcttgtcttaacagtcactaccagaggg
r, CTCATACTGGCCGCGAATGTCC
wt_f, CTCTATCAGCAGGAGATCCGGGA
All three primers can be mixed together.

Alignment of WT and Mutant Sequences w/ gRNA Targets (cyan) and Genotyping Primers (pink) Shown on WT Sequence

Allele

482bpD

WT Genotyping Size

387

WT Protein Sequence

MSYGSDHYMSSSYRKLFGDNPRFAGSRMSNVSPRSSMSSSGFRSQSVSRSSASPAGYYKR
SGRSSSFSPVHFDSVDFSQTSVLNNEFKIVRTNEKEQLQGLNDRFAMFIEKVRNLEQHNK
VLETELVSLRQRQNEPSRLAELYQQEIRDLRAQVDELNNEKSHILIERDSIEEDLQKLRG
KFEEEIRAREEAEQTLRSYKKDVDDATMVRVDLERKVESLLDEINFLRKVHDEEVTELTN
MIQAAQISVEVELSKPDLTSALKDIRGQYETLASKNLQSAEEWYKSKFASLNEQATRTNE
AMRATREEVNDYRRQLQSKTIEIETLRGTNESLERQIREMEEAHNAEVAGYQETIGQLDL
ELRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETHFSSGVTFSSTPSITYGY
QSRSAFTSTRNPKKEREEEGHPKSKTAAKREENTDENVGIKKTEKNDAVDVNSN-

Mutant Protein Sequence

MSYGSDH-

Mutant Genotyping Size

443

Ribosome Profiling Development

Transcript Plot

Sequence 2

Ensembl Gene Name

inab

Harvard Allele

a286

Mutation Area - WT DNA Sequence

tgcagtgaggaaggttgatgcgaggagaagcgtggctaaattattgattgggacggtcctgctataaaaggagacgccgccggagttctgctccttatcgtcaaacgccaagATGAGCTACGGATCCGACATCTACTCTGCCTCTTCCTACCGGAAGATCTTCGGAGATTCCACCCGTTTCTCAGCCTCTCCATCCCGGCTGAGCAGCTCCCGGAGCGGGTTTAAATCCCAGTCTGTGAACCGCCCCAACATCCCAAGCTCCTACAAGCGCTCCACCCGATCTGGCTTCCCGTCTTCTTCTCTGGACAGCTTCGATTTCACCCAGAGTACCGTGCTTAACAATGAGTTTAAAATCATCCGCACCAATGAGAAGGAGCAGATGCAAGGGCTCAACGACCGTTTCGCGATGTTCATTGAGAAAGTTCGCAATCTGGAGCAGCACAATAAAGTGCTGGAAACCGAACTCGTGACTCTGCGCCAGCGCCAGACAGAACCGTCCCGTCTGGCCGAACTTTACCAGCAGGAGATCCGCGAGCTGCGCTCCCAACTCGAGGAACTCAACGCCGAGAAGAACCAGATGATGTTCGAGCGCGACAGTATCGAGGAAGACCTACAGAAACTTCACGAGAAGTTTGAGGAAGAGATGAGAATGCGCGAGGAGGCCGAGCAAACCCTGAGAGCTTTCAAGAAGGACGTGGACAACGCCTCCATGGTGCGTCTAGACCTGGAGAAAAAGGTCGAATCCCTTCTGGATGAAATCAACTTTTTAAGGAAGGTGCACGAGGAGGAGGTGGCCGAGCTCATGAACATGATCCAGGCTAGCCAGGTGTCCGTGGAGATGGAAGTGGCCAAACCCGACCTCACCTCCGCCCTAAAGGATATTCGCGGCCAGTATGAAGCAATGGCGAGCAAGAACTTGCAGTCGGCTGAAGAGTGGTACAAGTCCAAGTTCGCCGACCTTAGCGAACAGGCCAACAAGAGCAACGAGGTCATTCGCGCTAGCAGGGAGGAGCTCAACGAGTTCAGGAGGCAGCTGCAGTCCAAGACCATCGAGATCGAGAGTCTGAGGGGTACAAATG

Mutation Area - Mutant DNA Sequence

tgcagtgaggaaggttgatgcgaggagaagcgtggctaaattattgattgggacggtcctgctataaaaggagacgccgccggagttctgctccttatcgtcaaacgccaagATGAGCTACGGATCCGACATCTACTCTGCCTCTTCCTACCGGAAGATCTTCGGAGATTCCACCCGTTTCTCAGCCTCTCCATCCCGGCTGAGCAGCTCCCGGAGCGGGTTTAAATCCCAGTCTGTGAACCGCCCAAGCTCCTACAAGCGCTCCACCCGATCTGGCTTCCCGTCTTCTTCTCTGGACAGCTTCGATTTCACCCAGAGTACCGTGCTTAACAATGAGTTTAAAATCATCCGCACCAATGAGAAGGAGCAGATGCAAGGGCTCAACGACCGTTTCGCGATGTTCATTGAGAAAGTTCGCAATCTGGAGCAGCACAATAAAGTGCTGGAAACCGAACTCGTGACTCTGCGCCAGCGCCAGACAGAACCGTCCCGTCTGGCCGAACTTTACCAGCAGGAGATCCGCGAGCTGCGCTCCCAACTCGAGGAACTCAACGCCGAGAAGAACCAGATGATGTTCGAGCGCGACAGTATCGAGGAAGACCTACAGAAACTTCACGAGAAGTTTGAGGAAGAGATGAGAATAAGACGGTAAACAAAGAGAAGGCAGTGAGGGAGAAGGTGTTAAAGTGAACGGTGCAAGGAGGAGGCCGAGCAAACCCTGAGAGCTTTCAAGAAGGACGTGGACAACGCCTCCATGGTGCGTCTAGACCTGGAGAAAAAGGTCGAATCCCTTCTGGATGAAATCAACTTTTTAAGGAAGGTGCACGAGGAGGAGGTGGCCGAGCTCATGAACATGATCCAGGCTAGCCAGGTGTCCGTGGAGATGGAAGTGGCCAAACCCGACCTCACCTCCGCCCTAAAGGATATTCGCGGCCAGTATGAAGCAATGGCGAGCAAGAACTTGCAGTCGGCTGAAGAGTGGTACAAGTCCAAGTTCGCCGACCTTAGCGAACAGGCCAACAAGAGCAACGAGGTCATTCGCGCTAGCAGGGAGGAGCTCAACGAGTTCAGGAGGCAGCTGCAGTCCAAGACCATCGAGATCGAGAGTCTGAGGGGTACAAATG

Guide RNA Target Sites

GAAGATCTTCCGGTAGGAAGAGG
AGGAGCTTGGGATGTTGGGGCGG
GGAAGAGATGAGAATGCGCGAGG
GCGAATATCCTTTAGGGCGGAGG

Genotyping Primers

f, GCGCTCCCAACTCGAGGAACTCA
r, ACCTCCTCCTCGTGCACCTTCCT

Alignment of WT and Mutant Sequences w/ gRNA Targets (cyan) and Genotyping Primers (pink) Shown on WT Sequence

Allele

9bpD,54bpI

WT Genotyping Size

255

WT Protein Sequence

MSYGSDIYSASSYRKIFGDSTRFSASPSRLSSSRSGFKSQSVNRPNIPSSYKRSTRSGFP
SSSLDSFDFTQSTVLNNEFKIIRTNEKEQMQGLNDRFAMFIEKVRNLEQHNKVLETELVT
LRQRQTEPSRLAELYQQEIRELRSQLEELNAEKNQMMFERDSIEEDLQKLHEKFEEEMRM
REEAEQTLRAFKKDVDNASMVRLDLEKKVESLLDEINFLRKVHEEEVAELMNMIQASQVS
VEMEVAKPDLTSALKDIRGQYEAMASKNLQSAEEWYKSKFADLSEQANKSNEVIRASREE
LNEFRRQLQSKTIEIESLRGTNESLERQIHEMEDRHNAEIMGYQDSIGELENDLRTTKSE
MARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRISTGITYPTPASVSSYSYQSRLYSS
TSMSSKKEVKDDDDKQQSGKPGKGSSQSDDSKKNDKIDSGDLNSTNQKN-

Mutant Protein Sequence

MSYGSDIYSASSYRKIFGDSTRFSASPSRLSSSRSGFKSQSVNRPSSYKRSTRSGFPSSS
LDSFDFTQSTVLNNEFKIIRTNEKEQMQGLNDRFAMFIEKVRNLEQHNKVLETELVTLRQ
RQTEPSRLAELYQQEIRELRSQLEELNAEKNQMMFERDSIEEDLQKLHEKFEEEMRIRR-

Mutant Genotyping Size

309

Ribosome Profiling Development

Transcript Plot

Behavior Data

Behavior Data Summary

None

Behavior Data Description 1

Dark flash block 1 start Merged section Pvalue = not significant 26 hethet vs 18 homhom ribgraph_mean_ribbon_fullboutdata_dpix_a0darkflash103.png

Behavior Data Graph 1

Behavior Data Description 2

Day all prepulse tap Merged section Pvalue = not significant 26 hethet vs 18 homhom ribgraph_mean_ribbon_fullboutdata_dpix_dayprepulseinhibition100d.png

Behavior Data Graph 2

Behavior Data Description 3

Features of movement entire protocol Graph Pvalue = not significant Merged section Pvalue = not significant 26 hethet vs 18 homhom ribgraph_mean_ribbonbout_aveboutdisp_10min_combo.png

Behavior Data Graph 3

Behavior Data Description 4

Frequency of movement entire protocol Graph Pvalue = not significant Merged section Pvalue = not significant 26 hethet vs 18 homhom ribgraph_mean_ribbonbout_dpixnumberofbouts_10min_combo.png

Behavior Data Graph 4

Behavior Data Description 5

Location in well entire protocol Graph Pvalue = not significant Merged section Pvalue = not significant 26 hethet vs 18 homhom ribgraph_mean_ribbonbout_averhofrac_10min_combo.png

Behavior Data Graph 5

Behavior Data Description 6

None

Behavior Data Graph 6

None

Behavior Data Description 7

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Behavior Data Graph 7

None

Behavior Data Description 8

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Behavior Data Graph 8

None

Behavior Data Description 9

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Behavior Data Graph 9

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Behavior Data Description 10

None

Behavior Data Graph 10

None

Behavior Data Description 11

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Behavior Data Graph 11

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Behavior Data Description 12

None

Behavior Data Graph 12

None

Behavior Data Description 13

None

Behavior Data Graph 13

None

Behavior Data Description 14

None

Behavior Data Graph 14

None